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Kristina Circelli
Director of Marketing
kcircelli@mymhs.com

Mindful Health Solutions Expands Access to Breakthrough MindfulONE One-Day TMS Technology

Mission Viejo, CA (November 3, 2025) – Mindful Health Solutions is proud to announce the expansion of MindfulONE – our next-generation depression treatment protocol that delivers rapid, durable relief in just one day — �� to its Mission Viejo clinic. This expansion marks the third clinic to offer MindfulONE, in addition to our San Francisco (Post Street) and Seattle locations. 

MindfulONE is a revolutionary approach to depression therapy, condensing the traditional 36-day treatment course into just one day. Not only does this eliminate the burden of travel, work, and time constraints, but also allows patients to experience full treatment effects within 1 to 6 weeks, up to and including full remission of depression.  In fact, 70% of patients experience full remission with this revolutionary protocol. 

“MindfulONE is pushing the frontiers of interventional psychiatry,” says Dr. Tobias Marton, Chief Medical Officer of Mindful Health Solutions. “It brings new hope to patients by combining speed, safety, and sustained efficacy in a way that transforms how we treat mood disorders, including both unipolar and bipolar depression. We are proud to now offer MindfulONE to our Mission Viejo community, in addition to San Francisco and Seattle.” 

How MindfulONE Works
MindfulONE combines a one-time, pre-treatment dose of two safe medications to prepare the brain for change, followed by 20 brief stimulation sessions administered over the course of a single day. Accelerated TMS is proven safe and effective, administered as an outpatient procedure at our Mission Viejo clinic. 

What is Transcranial Magnetic Stimulation?
FDA approved in 2008, Transcranial Magnetic Stimulation (TMS) is an alternative interventional psychiatric treatment for Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD), as well as related mood and anxiety disorders. During treatment, TMS coils deliver highly targeted, localized electromagnetic pulses to areas of the brain with reduced electrical activity, stimulating the release of neurotransmitters and hormones such as serotonin and dopamine. Once these neurons are stimulated by TMS, they continue to release neurotransmitters for a longer period of time compared to other treatments like antidepressants. 

At Mindful Health Solutions, we are dedicated to helping our communities heal from the devastating hold of depression, and are proud to be reaching more in need with this expansion. Learn more about MindfulONE and how patients can book a session here.

 About Mindful Health Solutions
Mindful Health Solutions is one of the nation’s leading providers of innovative behavioral health care and is the second-largest administrator of SPRAVATO (esketamine) in the nation. At all times, we remain focused on cutting-edge interventional psychiatric research and treatment protocols such as TMS, SPRAVATO (esketamine), and Ketamine Infusion Therapy for patients struggling with treatment-resistant depression and other psychiatric illnesses. Our experienced clinical team is dedicated to applying groundbreaking therapies supported by positive outcome data, academic rigor, and years of expertise in novel therapeutics. Outpatient clinics are located in California, Texas, and Washington. Learn more via our website.