A woman looking hopeful on a city street while the sun sets | Navigating Spravato Therapy Setbacks Maintaining Hope and Your Next Steps | Mindful Health Solutions

Spravato (esketamine) has become an exciting treatment option for those struggling with treatment-resistant depression (TRD). For many, this medication offers much-needed relief after trying other depression treatments without success. However, like with any treatment, there can be setbacks, including the return of depressive symptoms after an initial period of progress. These setbacks can feel discouraging, but they don’t mean the treatment has failed. In this blog, we’ll discuss why setbacks happen, how to cope emotionally, and how to maintain hope while taking practical next steps to manage your symptoms.

Disclaimer: The information provided in this blog is for educational purposes only and should not be considered medical advice. Always consult with a healthcare professional before making any changes to your treatment plan or starting a new therapy. Individual results may vary, and what works for one person may not work for another. If you’re experiencing severe symptoms, please seek immediate medical attention.

Understanding Setbacks in Spravato Therapy

It’s important to understand that setbacks can occur even after seeing initial success with Spravato. The return of depressive symptoms doesn’t necessarily mean the treatment is ineffective. Depression is a complex condition, particularly when it’s classified as treatment-resistant. Symptoms can fluctuate, and your mood may vary over time. It’s natural to feel disappointed when symptoms return, but this doesn’t mean your progress is lost. It’s part of the journey with TRD, and setbacks can often signal the need for adjustments in your treatment plan.

Treatment-resistant depression is a condition that typically requires a multifaceted, long-term approach. Individuals with TRD may respond well to treatment initially but then find that their symptoms fluctuate over time. This doesn’t mean the treatment has stopped working but may indicate that your brain is adjusting, or that other factors in your life are impacting your symptoms. Every patient’s journey is unique, and setbacks are often part of the process. Being aware of this can help manage your expectations and reduce the frustration of these challenges.

Why It’s Important to Communicate with Your Provider

When setbacks occur, it’s crucial to maintain open lines of communication with your healthcare provider. Regular check-ins allow your provider to monitor your progress and adjust your treatment plan as needed. If you notice a return of depressive symptoms, contact your provider promptly to discuss your experience. Being proactive about any mood changes can help ensure you’re getting the most out of your treatment.

One of the strengths of Spravato therapy is its flexibility. If depressive symptoms return, your healthcare provider may suggest adjustments, such as changing the dosage or frequency of treatments. In some cases, combining Spravato with other antidepressant medications or therapies like cognitive-behavioral therapy (CBT) can enhance results. Depression is a multifaceted condition, and it often requires a dynamic treatment plan. Be sure to stay engaged with your mental health team so that your care plan can be tailored to your evolving needs.

Interested in starting psychotherapy to complement your Spravato treatment?

Schedule an appointment by calling (844) 867-8444 today.

How to Cope with the Emotional Impact of Setbacks

Experiencing a setback in your mental health treatment can trigger feelings of disappointment, frustration, or even fear. It’s natural to feel disheartened when progress feels uncertain, but there are several strategies to help manage these emotions. Journaling can be a helpful way to process your thoughts and feelings. Writing down your experiences allows you to reflect on them from a more objective standpoint. Additionally, mindfulness practices like meditation can help you stay grounded and present, even when dealing with emotional turbulence.

Therapy can also play a vital role in helping you cope with the emotional impact of a setback. Cognitive-behavioral therapy (CBT), in particular, is a valuable tool for identifying negative thought patterns and replacing them with healthier, more constructive ones. Working with a therapist can give you the space to process your feelings, identify triggers, and develop coping strategies tailored to your specific needs. When combined with Spravato, therapy can enhance your overall treatment experience and help you build resilience in the face of setbacks.

It’s important to approach setbacks with self-compassion. Healing is rarely a linear process, and being too hard on yourself during tough times can only make things harder. Instead, remind yourself that setbacks are a normal part of recovery. Practicing self-compassion—treating yourself with kindness and understanding—can help reduce the emotional burden of a setback. This patience with yourself is critical for long-term recovery.

Maintaining Hope in the Face of Setbacks

One effective way to maintain hope during setbacks is by tracking your progress over time. Keeping a mood journal can help you identify patterns in your symptoms and better understand what might be triggering your depressive episodes. Over time, you’ll likely notice that even with setbacks, there are moments of progress and improvement. Tracking these moments can help you see the bigger picture and recognize that healing is still happening, even if it doesn’t always feel that way.

It’s easy to focus on the negative when you’re in the midst of a setback, but celebrating small wins can help shift your mindset. Even small improvements—like getting out of bed on a tough day or completing a task you’ve been avoiding—are worth acknowledging. These moments are evidence that you are making progress, even if it’s slow. By focusing on these small victories, you can cultivate a more hopeful outlook and remind yourself that brighter days are ahead.

Next Steps if You’re Experiencing a Setback

Reassess Lifestyle Factors

Sometimes, external factors like stress, sleep patterns, diet, or exercise can play a significant role in how you feel. Reassessing these aspects of your lifestyle may help you regain control over your mental health. For example, poor sleep can worsen depression symptoms, while regular physical activity has been shown to boost mood and overall well-being. Taking stock of your current lifestyle and making small adjustments may complement your Spravato treatment and improve your mood.

Consider Complementary Therapies

In addition to Spravato, several complementary therapies can help enhance your overall treatment. Cognitive-behavioral therapy (CBT), mindfulness practices, and support groups can offer additional tools to manage depressive symptoms. These therapies provide a holistic approach to mental health care, helping you cope with setbacks and develop long-term strategies for maintaining your well-being.

Stay Committed to the Process

Perhaps the most important next step is to stay committed to the process. Setbacks are a natural part of any long-term treatment plan, but with persistence, they can be managed. Stay in touch with your healthcare provider, be open to making adjustments to your treatment plan, and remain engaged with your mental health care. With time, you’ll likely see continued progress and relief from your symptoms.


Setbacks during Spravato therapy can feel discouraging, but they don’t mean that your journey is over. By staying in close communication with your healthcare provider, exploring complementary therapies, and maintaining hope, you can continue on your path to recovery. Healing may not be linear, but with persistence and support, managing treatment-resistant depression is possible. If you or a loved one are experiencing a setback with Spravato or any other treatment, reach out to Mindful Health Solutions at (844) 867-8444 for personalized care and support.

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