Man with head in hands on beach | Unraveling the Five Major Risk Factors for Clinical Depression

We all experience a wide range of emotions in our daily lives, from high moments of joy and excitement to low moments of sorrow and disappointment. However, when the feelings of sadness persist and start interfering with daily activities, it may signal a deeper issue – clinical depression. This topic, while it might seem heavy, is very important because clinical depression affects millions of people worldwide. Keep reading to learn the primary risk factors to help raise awareness and pave the way for the prevention and appropriate treatment of clinical depression.

Understanding Clinical Depression

Before we go over the risk factors, let’s take a moment to understand what clinical depression is. This mental health disorder is also known as major depressive disorder. It’s characterized by persistent feelings of sadness and a loss of interest in activities once enjoyed. Unlike temporary emotional responses to challenges in everyday life, clinical depression changes how you think, feel, and function in daily activities. Symptoms might include sleep disturbances, changes in appetite, difficulty concentrating, and many more.

Clinical depression is a serious condition, but remember, it is also treatable. Effective treatments often include a combination of medication, psychotherapy, and lifestyle changes. Understanding the risk factors is a vital part of the picture, helping us know who might be more susceptible to this condition, and why.

Risk Factor #1: Genetics

You’ve probably heard that certain traits can run in families – from the color of your hair to your height or even your artistic talent. This fact is also true when it comes to certain health conditions, including mental health disorders like clinical depression. Some individuals are more likely to experience depression due to their genetic makeup. It’s important to note that having a family member with depression doesn’t guarantee you’ll experience it; it just means your chances might be higher compared to someone with no family history of depression.

Risk Factor #2: Traumatic or Stressful Life Events

Life isn’t always smooth sailing. Sometimes, we go through particularly difficult periods such as the loss of a loved one, going through a divorce, or losing a job. Traumatic experiences such as physical or emotional abuse can also leave deep scars. These significant life events and trauma can trigger depressive episodes in some individuals. It’s crucial to understand that not everyone who experiences these life events will develop depression. But for some people, particularly if there are other risk factors at play, these events can indeed trigger the onset of depression.

Has a Traumatic Experience Caused You to Have Post-Traumatic Stress Disorder?

Risk Factor #3: Substance Abuse

There is a strong correlation between substance abuse and depression. It is estimated that about one-third of individuals suffering from substance abuse disorders also struggle with clinical depression. Unfortunately, this can often become a harmful cycle. Those struggling with depression may turn to substances as a form of self-medication. In turn, these substances can increase feelings of sadness and hopelessness, leading to further substance use.

Risk Factor #4: Chronic Medical Conditions

Living with a chronic medical condition can be physically and emotionally taxing. Conditions like heart disease, cancer, diabetes, or chronic pain can significantly impact an individual’s quality of life and are often associated with higher rates of depression. The constant worry and stress of managing these conditions can trigger depression or make existing symptoms worse.

Risk Factor #5: Personal or Family History of Mental Health Disorders

Personal history of mental health issues also contributes to the risk of developing depression. If you’ve had a previous episode of depression or another mental health disorder, you’re at a higher risk of experiencing depression again.

Depression Prevention and Coping Strategies

Although we can’t always control these risk factors, there are strategies we can employ to support our mental health. Regular physical activity, a balanced diet, and adequate sleep are some of the fundamental building blocks of mental well-being. Staying socially connected and seeking support when necessary can also play a crucial role in maintaining mental health.


Learn 5 simple steps you can take today to improve your mental health.

Moreover, if you identify these risk factors in yourself or a loved one, reaching out to a mental health professional can be an important step. It’s not a sign of weakness to ask for help but rather a proactive step towards improved mental health.

Call us today at 844-867-8444 to get customized mental health support for your unique needs.

Treatment Options for Clinical Depression

Before we conclude, it’s important to highlight the available treatments for clinical depression. If you, or someone you know, are dealing with this condition, you should know there are several effective treatment options. They range from traditional therapies to innovative approaches for those with treatment-resistant depression.

1. Psychotherapy and Medication

Psychotherapy, or talk therapy, is a common and effective treatment for depression. Cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT) are among the most researched and widely used forms of therapy. In these sessions, trained mental health professionals help individuals understand their thoughts, behaviors, and relationships to improve their mental health.

Antidepressant medication is another common treatment. Medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), work by altering the brain to help improve mood and reduce feelings of despair.

Often, a combination of medication and psychotherapy is the most effective treatment plan.

2. TMS (Transcranial Magnetic Stimulation)

For those who have not responded to traditional treatment methods, Transcranial Magnetic Stimulation might be an option. TMS is a non-invasive procedure that uses magnetic fields to stimulate nerve cells in the brain. It’s particularly used when other treatments haven’t been successful.

Explore these 3 reasons to try TMS for treating depression.

3. Esketamine and Ketamine Infusion Therapy

Esketamine nasal spray is a newer treatments that the FDA has approved for individuals with treatment-resistant depression. A derivative of ketamine, which has been used for years as an anesthetic, esketamine has been found to have rapid antidepressant effects. It’s often used when other treatment options have failed.

Ketamine infusion therapy is not yet FDA-approved, but has been found to be effective for patients struggling with a number of psychiatric conditions, including treatment-resistant depression (TRD), anxiety disorders, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and suicidal ideation. 

Learn more about the differences and similarities of esketamine and ketamine treatments for depression.

It’s essential to remember that while these treatments can be effective, they are not without risks or side effects. Therefore, they should be used under the direct supervision of a healthcare provider.

Always consult with a healthcare professional or mental health expert to discuss the most appropriate treatment options based on individual needs and circumstances.


Clinical depression, while a serious and often debilitating condition, does not have to dictate one’s life. With numerous treatment options available, it is entirely possible to manage this condition and lead a fulfilling life. Understanding the risk factors is a key part of the process, as is seeking help when needed. Remember, there is no shame in reaching out for support, and every step taken towards better mental health is a step worth taking. If you are looking for help with your mental health, we are here for you. Give us a call at 844-867-8444 and we can discuss how to provide you with the support you deserve.

Take a free mental health quiz
Book an Appointment