How To Prepare for Your Esketamine Nasal Spray Treatment

Depression can be a debilitating illness with symptoms that many people struggle with throughout their lives. However, there may be hope on the horizon. Esketamine nasal spray is a prescription medicine used to treat treatment-resistant depression. In many cases, it has been found to reduce depressive symptoms and improve outlook after the first treatment. Learn more about this innovative option and how to prepare for your first treatment.

What is esketamine nasal spray?

Esketamine nasal spray is a prescription medicine used to treat adults living with treatment-resistant depression (TRD). TRD is diagnosed when someone struggling with major depressive disorder hasn’t found relief after trying two or more medications.

Esketamine works by helping to increase communication between nerve cells, which restores balance to certain areas of the brain. Esketamine nasal spray is given as part of a treatment plan which often includes psychotherapy and life changes. This treatment may help improve and restore feelings of well-being and enthusiasm for life that many people struggle with. 

Learn more about what esketamine is and how it works.

How esketamine helps treat depression

Using esketamine as a treatment offers several benefits to people living with depression. As it is most often taken in conjunction with other depression treatments, it can provide improved symptoms more quickly.

In many cases, it has been found to reduce depressive symptoms and improve outlook after the first treatment. Additionally, with its fast-acting formula, the effects can be felt within several hours of taking the medication. As depression can be a long-term and complex illness, this quick relief can be extremely beneficial. However, it is important to note that the full effects of treatment won’t be felt until completing the full course, which usually consists of 12 treatments over two months.

The 5 amazing benefits of esketamine nasal spray.

What to expect for treatment

Before receiving esketamine nasal spray treatment, it is important to understand what to expect before and during the treatment. Before beginning treatment, the doctor will likely go over any medications currently being taken as well as any potential interactions with esketamine. The doctor may also advise avoiding certain activities before the treatment, such as drinking alcohol, operating machinery, or taking vigorous exercise. Additionally, the doctor may advise avoiding any activities that may make the side effects more intense, such as high-stress activities.

Since esketamine is considered a controlled substance, treatments will take place in a clinical setting. During the treatment, patients will self-administer the nasal spray and be monitored by a healthcare professional.

Patients will stay at the healthcare provider’s office for at least two hours after receiving the treatment. The doctor will also want the patient to be picked up or take a ride home. After treatment, some people feel a little out of it. Patients will not be able to drive after and will want to arrange for transportation home ahead of time. They also may not be able to go to work or school directly after.   

How to prepare for treatment

It is essential to follow the doctor’s instructions when preparing for an esketamine nasal spray treatment. Eating and drinking instructions provided by the doctor should be kindly followed. Additionally, it is important to avoid caffeine or sugary foods or drinks for at least eight hours.

Before the esketamine nasal spray treatment, make sure to bring everything needed for the appointment. This should include medication information, such as the names and doses of any medications taken, and insurance information. For the sake of convenience, it is useful to bring a list of all questions or concerns that may come up. Patients should also plan to bring a driver to the appointment or arrange for transportation home as part of the aftercare instructions. 

It is vital to talk openly with the doctor before an esketamine nasal spray treatment. The doctor should be informed of any other medications being taken, as some medicines may interact with the esketamine nasal spray. It is also important to bring up any chronic illnesses or conditions before the treatment, such as asthma or high blood pressure. Patients should also tell their doctor about any psychiatric conditions, such as bipolar disorder or schizophrenia, before beginning esketamine nasal spray treatment. 

Esketamine nasal spray side effects to be aware of

Esketamine nasal spray has the potential to cause several side effects, including nausea, dizziness, and drowsiness. While these effects cannot be completely avoided, several steps can be taken to reduce them. Drinking plenty of fluids and limiting movement after the treatment can help reduce the chances of dizziness or lightheadedness. It is also important to get rest before and after the treatment, as fatigue can result in increased side effects. 

Learn more about the side effects of esketamine.


Esketamine nasal spray can be a beneficial treatment option for those looking to reduce their depressive symptoms. To ensure its effectiveness, it is important to properly prepare and follow all the necessary steps before the appointment. This includes understanding what to expect during the treatment, such as eating and drinking instructions, what to bring to the appointment, and discussing medication with the doctor.

If you think esketamine nasal spray could be the right treatment option for you, call us at 844-867-8444 to schedule a free mental health consultation. You deserve to feel better.

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